Faster DNA Synthesis without Hazardous Waste

There has been an exciting molecular biology method development reported in Nature Biotechnology!  DNA is normally synthesized through the nucleoside phosphoramidite method that was first published in 1981.  Joint Bioenergy Institute (JBEI) researchers and their collaborators have demonstrated proof of concept for a new enzymatic based method that has many advantages.  The new method increases the speed off DNA synthesis. It removes the need for solvent use, which is a hazardous waste. Overall it will drop the cost of synthesizing DNA.  It's terrific work, and an advance that we at Labconscious applaud as a greener biochemistry method for life science laboratory work.  

Watch the JBEI video below, read the full story on the JBEI website here, and review all the technical details in the report  De novo DNA Synthesis Using Polymerase-Nucleotide Conjugates (2018) Nature Biotechnology. 

Researchers at the Joint BioEnergy Institute (JBEI), announced they have pioneered a new way to synthesize DNA sequences through a creative use of enzymes that promises to be faster, cheaper, and more accurate. The discovery, led by JBEI graduate students Sebastian Palluk and Daniel Arlow, was published in Nature Biotechnology in a paper titled "De novo DNA Synthesis Using Polymerase-Nucleotide Conjugates."